Al-Ferjiani, A., Kennedy, S. and Salt, I. (2025) The effect of AMPKα1 deletion on anticontractile activity and FGF-21 release by mouse abdominal aortic perivascular adipose tissue (PVAT). [Data Collection]
Collection description
This data is from a study designed to investigate the role of AMPK in endothelium-dependent anticontractile effects of PVAT and which PVAT-derived factors could be involved. It contains data on vascular function using myography to measure contraction and relaxation of mouse aortic rings from wild-type (WT) and global AMPKα1 knockout (KO) aortic rings. It also has secretory function of aortic PVAT data from an immunoblotting array and ELISA, and gene expression data using qPCR. Human Umbilical Vein Endothelial Cells (HUVECs) and 3T3-L1 adipocytes how adding conditioned media (CM) derived from WT and KO PVAT affects eNOS expression, and nitric oxide (NO) release as well as AMPK-dependant pathways.
| College / School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular and Metabolic Health |
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| Date Deposited: | 20 Nov 2025 13:11 |
| URI: | https://researchdata.gla.ac.uk/id/eprint/2086 |
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