The endogenous calpain inhibitor calpastatin attenuates axon degeneration in murine Guillain-Barré syndrome

McGonigal, R. , Cunningham, M. , Smyth, D., Chou, M., Barrie, J., Wilkie, A., Campbell, C., Saatman, K. E., Lunn, M. and Willison, H. (2022) The endogenous calpain inhibitor calpastatin attenuates axon degeneration in murine Guillain-Barré syndrome. [Data Collection]

Original publication URL: https://doi.org/10.1111/jns.12520

Collection description

Study Aim: This study used established ex and in vivo acute and subacute mouse models of axonal Guillain-Barre syndrome (GBS)(AMAN) to study the therapeutic advantages of calpain inhibition to protect axon integrity and recovery.

Images were captured using Zeiss LSM or Zeiss AxioImager Z1 microscopes and observed using Zeiss Zen or ImageJ (FIJI) software. Quantification was performed using the same. Analysis output can be found in Excel sheets. Statistical analysis was performed using GraphPad software.

Funding:
College / School: College of Medical Veterinary and Life Sciences > School of Infection and Immunity
Date Deposited: 29 Nov 2022 15:27
URI: https://researchdata.gla.ac.uk/id/eprint/1360

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McGonigal, R. , Cunningham, M. , Smyth, D., Chou, M., Barrie, J., Wilkie, A., Campbell, C., Saatman, K. E., Lunn, M. and Willison, H. (2022); The endogenous calpain inhibitor calpastatin attenuates axon degeneration in murine Guillain-Barré syndrome

University of Glasgow

DOI: 10.5525/gla.researchdata.1360

Retrieved: 2024-06-22

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