Lee, L., Gadegaard, N. , Andrés, M. C. d., Turner, L.-A., Burgess, K., Yarwood, S., Wells, J., Mpoyi, E., Salmerón-Sánchez, M., Meek, R. D., Oreffo, R. and Dalby, M. (2016) Nanotopography controls cell cycle changes involved with skeletal stem cell self-renewal and multipotency. [Data Collection] (Unpublished)
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Collection description
We present data showing that individual skeletal stem cell populations respond to nanoscale topography differently, and that seeding protocols can be optimised to enhance self-renewal allowing nanotopography to be used as a tool for the study of multipotency. Biochemical, transcriptomic and metabolomic protocols were used to investigate roles for mitogen activated protein kinases as a self-renewal / differentiation control switch and implicate control of cell cycle as being critical for maintenance of multipotency in prolonged culture. This has clear implications for production of large-numbers of high quality skeletal stem cells in vitro.
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| College / School: | College of Medical Veterinary and Life Sciences > School of Molecular Biosciences College of Science and Engineering > School of Engineering > Biomedical Engineering |
| Date Deposited: | 12 Aug 2016 10:03 |
| URI: | https://researchdata.gla.ac.uk/id/eprint/341 |
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