Synthesis of cyclopropyl-substituted furans by Brønsted acid promoted cascade reactions

Clark, J. S., Romiti, F., Hogg, K., F., Hamid, M. H. S. A., Richter, S. C., Boyer, A., Redman, J. C. and Farrugia, L. J. (2015) Synthesis of cyclopropyl-substituted furans by Brønsted acid promoted cascade reactions. [Data Collection]

Original publication URL: http://dx.doi.org/10.1002/anie.201500625

Collection description

Chloroacetic acid promotes an efficient and diastereoselective intramolecular cascade reaction of electron-deficient ynenones to deliver products featuring a 2,3,5-trisubstituted furan bearing a fused cyclopropyl substituent at the 5-position. Synthetically relevant polycyclic building blocks featuring rings of various sizes and heteroatoms have been synthesized in high yield using this mild acid-catalyzed reaction.

Funding:
Keywords: Crystal structure
College / School: College of Science and Engineering > School of Chemistry
Date Deposited: 14 May 2015 10:27
Enlighten Publications URL: http://eprints.gla.ac.uk/106036/
URI: http://researchdata.gla.ac.uk/id/eprint/166

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Clark, J. S., Romiti, F., Hogg, K., F., Hamid, M. H. S. A., Richter, S. C., Boyer, A., Redman, J. C. and Farrugia, L. J. (2015); Synthesis of cyclopropyl-substituted furans by Brønsted acid promoted cascade reactions

University of Glasgow

DOI: 10.5525/gla.researchdata.166

Retrieved: 2022-08-19