952 27 4132 2 21395 document 4132 ReadMe_952.docx application/vnd.openxmlformats-officedocument.wordprocessingml.document 534fb8cf73452922b5d633d0c8d55a97 MD5 71402 2020-09-15 13:30:53 https://researchdata.gla.ac.uk/952/1/ReadMe_952.docx 952 1 1 application/vnd.openxmlformats-officedocument.wordprocessingml.document Text en public cc_by_4

ReadMe_952.docx

readme 4134 1 21400 document 4134 indexcodes.txt text/plain 02f037a87b2f5ff541413dc390ac4fc9 MD5 36973 2020-09-15 13:41:19 https://researchdata.gla.ac.uk/952/2/indexcodes.txt 952 2 2 text/plain other Generate index codes conversion from Text to indexcodes en public

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http://eprints.org/relation/isVersionOf https://researchdata.gla.ac.uk/id/document/4132 http://eprints.org/relation/isVolatileVersionOf https://researchdata.gla.ac.uk/id/document/4132 http://eprints.org/relation/isIndexCodesVersionOf https://researchdata.gla.ac.uk/id/document/4132 archive 6975 disk0/00/00/09/52 2020-03-12 12:39:34 2024-04-15 14:28:48 2020-03-12 12:39:34 data_collection show Hodgkinson Thomas Tsimbouri Monica 10319 0000-0001-5124-7458 Llopis-Hernandez Virginia 34222 0000-0002-7616-7347 Campsie Paul Scurr David Childs Peter 25713 Phillips David 35154 0000-0002-9480-5808 Donnelly Sam 40686 Wells Julia Salmeron-Sanchez Manuel 30067 0000-0002-8112-2100 Burgess Karl 8709 Alexander Morgan Vassalli Massimo 51777 0000-0002-3063-4376 Oreffo Richard Reid Stuart France David 14102 0000-0002-5409-3316 Dalby Matthew 9268 0000-0002-0528-3359 glaresearchdata:2020-03-12-952 pub 25400000 30100000 30303000 Data stored on owncloud. 225 transferred to data storage budget, transferred to library budget 6/7/21 Interest in bioactive, or activity, metabolites is growing. For adult stem cells in particular, the ability to target desired phenotypes with specificity and potency is important for provision of cellular therapies and also for drug discovery for tissue regeneration. Metabolomics provides a powerful tool for the discovery of bioactive metabolites, but bioinformatic pipelines are hindered by the quality of the input signal that drives the process being studied. For example, with mesenchymal stem cell (MSC) differentiation to bone forming osteoblasts, dexamethasone and bone morphogenetic protein 2 are commonly used stimuli in the lab and in clinic respectively. However, both can result in the artefactual production of adipocytes as well as osteoblasts and this could confound bioactive metabolite identification. Here, we use nanovibrational stimulation of MSCs to promote osteogenesis without adipogenesis and show that this can be used to identify bioactive metabolites with high osteogenic specificity. Further, these metabolites can have their structure-function relationship examined to provide both specificity and enhanced potency as we illustrate within this new work. 2020-03-12 published University of Glasgow 10.5525/gla.researchdata.952 University of Glasgow 173494 Rapid Bone Graft Synthesis Through Dual Piezoelectric/Nanomechaniocal Stimulation Matthew Dalby Biotechnology and Biological Sciences Research Council (BBSRC) BB/P00220X/1 Institute of Molecular, Cell & Systems Biology 173192 Engineering growth factor microenvironments- a new therapeutic paradigm for regenerative medicine Manuel Salmeron-Sanchez Engineering and Physical Sciences Research Council (EPSRC) EP/P001114/1 ENG - Biomedical Engineering 172525 Developing the NanoKick bioreactor to enable tissue engineered bone graft and use of metabolomics to identify bone specific drug candidates Matthew Dalby Engineering and Physical Sciences Research Council (EPSRC) EP/N013905/1 Institute of Molecular, Cell & Systems Biology FALSE English 2030-03-12 R FALSE TRUE https://eprints.gla.ac.uk/id/eprint/227614