869 23 3073 2 16959 document 3073 README-cell_metabolism_2018.docx application/vnd.openxmlformats-officedocument.wordprocessingml.document 7a5d7c89373ebd7a499636fefc754147 MD5 28082 2019-09-13 10:55:29 https://researchdata.gla.ac.uk/869/1/README-cell_metabolism_2018.docx 869 1 1 application/vnd.openxmlformats-officedocument.wordprocessingml.document Text en public cc_by_4

README-cell_metabolism_2018.docx

readme 3095 1 16986 document 3095 indexcodes.txt text/plain fcb73a8a42aa66ae6ff0425fd3018299 MD5 1706 2019-09-13 11:05:35 https://researchdata.gla.ac.uk/869/2/indexcodes.txt 869 2 2 text/plain other Generate index codes conversion from Text to indexcodes en public

indexcodes.txt

http://eprints.org/relation/isVersionOf https://researchdata.gla.ac.uk/id/document/3073 http://eprints.org/relation/isVolatileVersionOf https://researchdata.gla.ac.uk/id/document/3073 http://eprints.org/relation/isIndexCodesVersionOf https://researchdata.gla.ac.uk/id/document/3073 archive 5 disk0/00/00/08/69 2019-09-13 10:57:59 2025-06-12 12:28:30 2019-09-13 10:57:59 data_collection show Scopelliti Alessandro 15991 Bauer Christin 49560 Yu Yachuan 31602 Zhang Tong 35765 Kruspig Bjorn 34399 Murphy Daniel 29295 0000-0002-5538-5468 Vidal Marcos 31429 Maddocks Oliver 35457 0000-0002-5551-9091 Cordero Julia 31423 0000-0003-1701-9480 glaresearchdata:2019-08-23-869 pub 25101000 The control of systemic metabolic homeostasis involves complex inter-tissue programs that coordinate energy production, storage, and consumption, to maintain organismal fitness upon environmental challenges. The mechanisms driving such programs are largely unknown. Here, we show that enteroendocrine cells in the adult Drosophila intestine respond to nutrients by secreting the hormone Bursicon α, which signals via its neuronal receptor DLgr2. Bursicon α/DLgr2 regulate energy metabolism through a neuronal relay leading to the restriction of glucagon-like, adipokinetic hormone (AKH) production by the corpora cardiaca and subsequent modulation of AKH receptor signaling within the adipose tissue. Impaired Bursicon α/DLgr2 signaling leads to exacerbated glucose oxidation and depletion of energy stores with consequent reduced organismal resistance to nutrient restrictive conditions. Altogether, our work reveals an intestinal/neuronal/adipose tissue inter-organ communication network that is essential to restrict the use of energy and that may provide insights into the physiopathology of endocrine-regulated metabolic homeostasis. 2019-08-23 published University of Glasgow 10.5525/gla.researchdata.869 Image Spreadsheet Text 63302 1 Regulation of stem cell function during tissue homeostasis and transformation Julia Cordero Wellcome Trust (WELLCOTR) 104103/Z/14/Z RI CANCER SCIENCES FALSE EN https://doi.org/10.1016/j.cmet.2018.09.021 article 2029-09-13 R 2023-01-11 System note: This item was downloaded last on: Thu Jan 5 15:58:17 2023 so we could update the retention date to: 2033-01-05. It has had 24 downloads since 2013. FALSE TRUE http://eprints.gla.ac.uk/id/eprint/169751