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data archive 5 disk0/00/00/06/14 2018-05-03 09:12:24 2025-05-19 15:07:05 2018-05-03 09:12:24 data_collection show Maddocks Oliver 35457 0000-0002-5551-9091 Athineos Dimitris 14905 Cheung Eric C. Lee Pearl Zhang Tong 35765 van den Broek Niels J.F. Mackay Gillian 31521 Labuschagne Christiaan F. Gay David 41591 Kruiswijk Flore Blagih Julianna Vincent David Campbell Kirsteen 36098 Ceteci Fatih Sansom Owen 10777 0000-0001-9540-3010 Blyth Karen 8836 Vousden Karen 8674 glaresearchdata:2018-05-03-614 pub 25100000 The non-essential amino acids serine and glycine are used in multiple anabolic processes that support cancer cell growth and proliferation (reviewed in ref. 1). While some cancer cells upregulate de novo serine synthesis, many others rely on exogenous serine for optimal growth. Restriction of dietary serine and glycine can reduce tumour growth in xenograft and allograft models. Here we show that this observation translates into more clinically relevant autochthonous tumours in genetically engineered mouse models of intestinal cancer (driven by Apc inactivation) or lymphoma (driven by Myc activation). The increased survival following dietary restriction of serine and glycine in these models was further improved by antagonizing the anti-oxidant response. Disruption of mitochondrial oxidative phosphorylation (using biguanides) led to a complex response that could improve or impede the anti-tumour effect of serine and glycine starvation. Notably, Kras-driven mouse models of pancreatic and intestinal cancers were less responsive to depletion of serine and glycine, reflecting an ability of activated Kras to increase the expression of enzymes that are part of the serine synthesis pathway and thus promote de novo serine synthesis. 2018-05-03 published University of Glasgow 10.5525/gla.researchdata.614 Spreadsheet 66624 1 Targeting Tumour Metabolism for Cancer Therapy and Diagnosis. Oliver Maddocks Cancer Research UK (CRUK) 19702 RI CANCER SCIENCES FALSE EN http://dx.doi.org/10.1038/nature22056 article 2028-05-03 R FALSE FALSE http://eprints.gla.ac.uk/id/eprint/140432