Full funding statement: The support from the European Research Council (ERC HealIn- Synergy, 306990), the UK Medical Research Council (MR/L022710/ 1) and IOF-Marie Curie fellowship program (Protdel 331655) are acknowledged. RSS and MC acknowledge funding from MINECO-Spain through MAT2015-69315 (including FEDER funds). AJG acknowledges support from the NIH (R01 AR062368 and R01 AR062920).