This research was also funded by: • CVR (MC_UU_00034/3, MC_UU_00034/5 and MC_UU_00034/9) • G2P2 consortium (MR/Y004205) • BBSRC FLU-Trailmap (BB/Y007298/1) • Pirbright ISPG (BBS/E/PI/230001B) • CRUK core funding (A31287 and A1920) • DURABLE consortium - EU4Health Programme (101102733)