Funding: UK Medical Research Council grant MR/N008618/1 (AC) UK Medical Research Council grant MC_UU_00034/2 (AC) UK Medical Research Council grant MR/R009945/1 (EF) UK Medical Research Council grant MR/X008312/1 (EF) European Research Council starting grant EP/Y011414/1 (SJR) European Research Council Consolidator Grant (N# 101001634) (AC) EU H2020 support (DELTA-FLU; no. 727922) (PD) Wellcome Trust Fellowship 211222_Z_18_Z (ERG) UK Biotechnology and Biological Sciences Research Council Grant BB/P013740/1 (PD, ERG) UK Biotechnology and Biological Sciences Research Council Grant BB/X010937/1(PD, ERG, RMP) UK Biotechnology and Biological Sciences Research Council Grant BB/V011286/1 (PD, DRK) UK Biotechnology and Biological Sciences Research Council Grant BB/M027163/1 (PD, DRK) UK Biotechnology and Biological Sciences Research Council Grant BBS/E/RL/230002C (PD, ERG, RMP) UK Department for Food, Environment and Rural Affairs (Defra) contract no. SE2223 (PD) USDA-National Institute of Food and Agriculture Grant 2015-67015-22968 (DRK)