Thank you for your interest in these data: The following files contain the underlying data from the main figures and supplementary Material. The Source data.xlsx file contains the underlying data for all figures, with source data from each figure panel organised in a separate excel sheet within the excel workbook. Supplemental File 1.xlsx contains protein alignment data from all viruses used in the study. The .xlsx files can be accessed using any software that can read MS excel files. It may be helpful to access the publication explaining each figure (details below the file list). Deposited files: Source data.xlsx Supplemental File 1.xlsx For explanatory text, these data are the underlying data from: The potential of H5N1 viruses to adapt to bovine cells varies throughout evolution Matthew L. Turnbull1*, Mohammad Khalid Zakaria1*, Nicole S. Upfold1*, Siddharth Bakshi1, Callum Magill1, Udeet Ranjan Das1, Andrew T. Clarke1,2, Laura Mojsiejczuk1, Vanessa Herder1,2, Kieran Dee1, Nancy Liu1, Monika Folwarczna1, Georgios Ilia1, Wilhelm Furnon1,2, Verena Schultz1, Hanting Chen1, Ryan Devlin3, Jack McCowan3, Alex L. Young3, Wai-Wai Po1, Katherine Smollett1, Muhammad Ahsan Yaseen4,5, Rebecca Ross1, Avanti Bhide1, Bianca van Kekem2, Ron A.M. Fouchier2, Ana da Silva Filipe1, Munir Iqbal6, Ed Roberts3, Joseph Hughes1, Dirk Werling7, Pablo R. Murcia1**, Massimo Palmarini1,2** *These authors contributed equally to this work. **Co-corresponding authors Author Affiliations 1MRC-University of Glasgow Centre for Virus Research, Glasgow, UK 2Department of Viroscience, Erasmus Medical Centre, Rotterdam, The Netherlands 3CRUK Scotland Institute, Glasgow, UK 4Faculty of Veterinary Medicine, University of Teramo, Loc. Piano D’Accio, Teramo, Italy 5Istituto Zooprofilattico Sperimentale dell’ Abruzzo e Molise “G. Caporale”, Teramo, Italy 6The Pirbright Institute, Woking, UK 7Department for Pathobiology and Population Sciences, Centre for Vaccinology and Regenerative Medicine, Royal Veterinary College, London, UK Corresponding Authors: Pablo R. Murcia, Pablo.Murcia@glasgow.ac.uk Massimo Palmarini, m.palmarini@erasmusmc.nl