-----Data for: Fisher information for the design of diffuse optical brain monitoring systems Authors: Wang Z. G., Radford J., Sun M. J., Faccio D. Citation: Wang, Z. G., Radford, J., Sun, M. J., & Faccio, D. (2026). Optics Express 34(5): 8027–8042. -----Contents TPSF and Jacobian datasets used in the paper (Monte Carlo simulations). -----Folder summary MCX_data_2D_head_model: Contains TPSF and Jacobian data from the 2D simplified head model (no CSF). Multiple anomaly depths and multiple S–D configurations included. MCX_data_CSF_2D_head_model: Same as above but for the 2D head model that includes a CSF layer. MCX_data_3D_head_model: 3D model results. TPSF and Jacobian for four S–D positions and for several anomaly depths. -----S–D ordering convention Ordering of S–D pairs in files: traverse all detectors top → bottom, and for each detector traverse all sources. (i.e. (D1,S1),(D1,S2),…,(D2,S1),…). See Fig. 1(a) in the paper for the geometry. -----Notes Each TPSF corresponds to one S–D pair, one anomaly depth, and one model geometry. Jacobians match the same conditions. Simulation parameters and optical properties are described in the manuscript. -----How to cite the data Please cite the paper above when using these data. -----Contact For questions about the data, contact the corresponding author listed in the article.