The 'Short Course Oncology Treatment' (SCOT) trial

Paul, J. , Boyd, K. , Briggs, A. , Cassidy, J., Harkin, A. and Iveson, T. (2019) The 'Short Course Oncology Treatment' (SCOT) trial. [Data Collection]

Not all data is available to download from this page. Usually this is because the dataset is too large or it is restricted in some way.

Collection description

6 months of oxaliplatin-containing chemotherapy is usually given as adjuvant treatment for stage 3 colorectal cancer. We investigated whether 3 months of oxaliplatin-containing chemotherapy would be non-inferior to the usual 6 months of treatment. Methods: The SCOT study was an international, randomised, phase 3, non-inferiority trial done at 244 centres. Patients aged 18 years or older with high-risk stage II and stage III colorectal cancer underwent central randomisation with minimisation for centre, choice of regimen, sex, disease site, N stage, T stage, and the starting dose of capecitabine. Patients were assigned (1:1) to receive 3 months or 6 months of adjuvant oxaliplatin-containing chemotherapy. The chemotherapy regimens could consist of CAPOX (capecitabine and oxaliplatin) or FOLFOX (bolus and infused fluorouracil with oxaliplatin). The regimen was selected before randomisation in accordance with choices of the patient and treating physician. The primary study endpoint was disease-free survival and the non-inferiority margin was a hazard ratio of 1·13. The primary analysis was done in the intention-to-treat population and safety was assessed in patients who started study treatment. This trial is registered with ISRCTN, number ISRCTN59757862.

College / School: College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences > Clinical Trials Unit
College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing
Date Deposited: 26 Sep 2019 12:03
Funder's Name: Medical Research Council (MRC), National Institute for Health Research (NIHR), Cancer Research UK (CRUK), Cancer Research UK (CRUK)
URI: http://researchdata.gla.ac.uk/id/eprint/819

Available Files

Documentation

Read me

Repository Staff Only: Update this record

Paul, J. , Boyd, K. , Briggs, A. , Cassidy, J., Harkin, A. and Iveson, T. (2019); The 'Short Course Oncology Treatment' (SCOT) trial

University of Glasgow

DOI: 10.5525/gla.researchdata.819

Retrieved: 2020-10-24

Downloads

Downloads per month over past year