Nanotopography controls cell cycle changes involved with skeletal stem cell self-renewal and multipotency

Lee, L. C. Y., Gadegaard, N., Andrés, M. C. d., Turner, L.-A., Burgess, K. V., Yarwood, S., Wells, J., Mpoyi, E., Salmerón-Sánchez, M., Meek, R. M. D., Oreffo, R. and Dalby, M. J. (2016) Nanotopography controls cell cycle changes involved with skeletal stem cell self-renewal and multipotency. [Data Collection] (Unpublished)

Enlighten Publications URI: http://eprints.gla.ac.uk/id/eprint/131930

Collection description

We present data showing that individual skeletal stem cell populations respond to nanoscale topography differently, and that seeding protocols can be optimised to enhance self-renewal allowing nanotopography to be used as a tool for the study of multipotency. Biochemical, transcriptomic and metabolomic protocols were used to investigate roles for mitogen activated protein kinases as a self-renewal / differentiation control switch and implicate control of cell cycle as being critical for maintenance of multipotency in prolonged culture. This has clear implications for production of large-numbers of high quality skeletal stem cells in vitro.

College / School: College of Medical Veterinary and Life Sciences > Institute of Molecular Cell and Systems Biology
College of Science and Engineering > School of Engineering > Biomedical Engineering
Date Deposited: 12 Aug 2016 10:03
Retention date: August 2026
Funder's Name: Biotechnology and Biological Sciences Research Council (BBSRC), Biotechnology and Biological Sciences Research Council (BBSRC), Biotechnology and Biological Sciences Research Council (BBSRC)
URI: http://researchdata.gla.ac.uk/id/eprint/341

Available Files

There are no files in this dataset stored in the repository.

Please follow the links below to access data held elsewhere.

Repository Staff Only: Update this record

Lee, L. C. Y., Gadegaard, N., Andrés, M. C. d., Turner, L.-A., Burgess, K. V., Yarwood, S., Wells, J., Mpoyi, E., Salmerón-Sánchez, M., Meek, R. M. D., Oreffo, R. and Dalby, M. J. (2016); Nanotopography controls cell cycle changes involved with skeletal stem cell self-renewal and multipotency

University of Glasgow

DOI: 10.5525/gla.researchdata.341

Retrieved: 2018-10-21